Cytochrome P-450 CYP3A

A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

Also Known As:

CYP3A4; CYP3A5; Cytochrome P-450 CYP3A4; Cytochrome P-450 CYP3A5; Cytochrome P-450IIIA; Cytochrome P450 3A; Cytochrome P450 3A4; Cytochrome P450 3A5; Erythromycin N-Demethylase; Taurochenodeoxycholate 6-alpha-Monooxygenase; 3A5, Cytochrome P450; 6-alpha-Monooxygenase, Taurochenodeoxycholate; Cytochrome P 450 CYP3A; Cytochrome P 450 CYP3A4; Cytochrome P 450 CYP3A5; Cytochrome P 450IIIA; Erythromycin N Demethylase; N-Demethylase, Erythromycin; P-450 CYP3A, Cytochrome; P-450 CYP3A4, Cytochrome; P-450 CYP3A5, Cytochrome; P-450IIIA, Cytochrome; P450 3A, Cytochrome; P450 3A5, Cytochrome; Taurochenodeoxycholate 6 alpha Monooxygenase; CYP3A

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 3: 9
        Cytochrome P-450 CYP3A: 2017
    - Oxidoreductases Acting on CH-NH Group Donors
      - N-Demethylating Oxidoreductases: 18
        Cytochrome P-450 CYP3A: 2017
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Cytochrome P450 Family 3: 9
      - Cytochrome P-450 CYP3A: 2017
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 3: 9
        Cytochrome P-450 CYP3A: 2017

Simone Lazar Selected Research

Simone Lazar Research Topics

Disease

Drug/Important Bio-Agent (IBA)